Brand Name

Coreg {GlaxoSmithKline}

Generic Name

carvedilol, pronounced KAR ve dil ole

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Drug Guide

The information contained in the following drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.

What is Coreg?

Coreg is a medication that is used to treat high blood pressure and heart failure. Coreg is in
a class of medications called beta blockers, and works to help the blood flow through your
arteries and veins. Patients who have recently experienced a heart attack may also be prescribed
Coreg. Coreg may be used for purposes not indicated in this medication guide.

Key Facts About Coreg

Drinking alcohol can increase certain side effects of Coreg. You should not drink alcohol
while taking Coreg. If you do drink alcohol do not take Coreg CR within 2 hours before or after
drinking. The extended-release Coreg CR may be released too quickly into your body if you drink
alcohol. Be sure to check the labels of any prescription or over-the-counter medicines, such as
cold medications, to see if they contain alcohol, which is also called ethanol.

Coreg is a part of a complete program that your doctor has prescribed for you. This program
includes diet, exercise, weight control, and possibly other medications. Follow your diet,
medication, and exercise routines closely.

Coreg is in FDA pregnancy category C. We do not know if Coreg can harm an unborn baby. Tell
your doctor if you are pregnant or if you plan to become pregnant before taking Coreg. It is also
not known whether Coreg passes into breast milk and could cause harm to a nursing baby. You
should not breast-feed while you are taking Coreg.

While you are taking Coreg try to avoid getting up too fast from a sitting or lying position,
as it may cause you to feel dizzy. Be cautious when getting up, and do so slowly to avoid
falling.

Before You Take Coreg

You should not take Coreg if you are allergic to carvedilol.

Tell your doctor if you have liver disease, diabetes, asthma, bronchitis or emphysema.

Before taking Coreg, tell your doctor if you have a serious heart condition such as heart
block, sick sinus syndrome, or slow heart rate (unless you have a pacemaker), angina or low blood
pressure

Let your doctor know if you have kidney disease, a thyroid disorder, a pheochromocytoma (tumor
of the adrenal gland), circulation problems likeRaynaud’s syndrome) or a history of
allergies.

If you plan to have cataract surgery be sure to tell your doctor or surgeon know that you are
being treated with Coreg. Coreg can affect your pupils during cataract surgery. Do not stop using
Coreg before surgery unless your surgeon tells you to.

You will need to have your blood pressure checked regularly while taking Coreg. Continue using
Coreg even if you feel well. High blood pressure often has no symptoms. You may need to use Coreg
or another blood pressure medication for the rest of your life.

Coreg Drug Interactions

You should inform your doctor if you are taking any of the following:

• allergy treatments or medications
• antidepressants like amitriptyline (Elavil, Vanatrip, Limbitrol), bupropion (Wellbutrin,
  Zyban), clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine
  (Prozac, Sarafem), imipramine (Tofranil), paroxetine (Paxil), and sertraline (Zoloft)
• blood pressure or heart medications like amlodipine
• Norvasc, Caduet, Exforge, Lotrel,
  Tekamlo, Tribenzor, Twynsta), clonidine (Catapres), diltiazem (Cartia, Cardizem), nifedipine
  (Nifedical, Procardia), reserpine and verapamil (Calan, Covera, Isoptin, Verelan)
• cimetidine (Tagamet)
• cyclosporine (Gengraf, Neoral, Sandimmune)
• fluconazole (Diflucan)
• heart rhythm medications like amiodarone (Cordarone, Pacerone), digoxin (digitalis, Lanoxin),
  flecainide (Tambocor), propafenone (Rythmol), and quinidine (Quin-G)
• HIV or AIDS medicine like delavirdine (Rescriptor) and ritonavir (Norvir, Kaletra)
• insulin or oral diabetes medication
• MAO inhibitors like furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil),
  rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar) and tranylcypromine (Parnate)
• medications to prevent or treat nausea and vomiting like metoclopramide (Reglan) and
  promethazine (Pentazine, Phenergan, Anergan, Antinaus);
• medications to treat psychiatric disorders like aripiprazole (Abilify), chlorpromazine
  (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon),
  and thioridazine (Mellaril)
• methadone (Methadose, Diskets, Dolophine)
• rifampin (Rifadin, Rifater, Rifamate)
• propoxyphene (Daron, Darvocet)

Other drugs you take that are not listed may interact with Coreg. You should tell your doctor
about all of the medications you use. This includes prescription drugs, vitamins, supplements and
herbal products, and over the counter medications. You should not begin taking a new medication
without telling your doctor first.

Directions for Taking Coreg

You should follow the instructions on your prescription label and not take Coreg for longer
than recommended by your doctor, or in larger or smaller doses.

Coreg should be taken once a day, preferably with food.

If you are switched from Coreg tablets to Coreg extended-release capsules (Coreg CR), your
daily total dose of this medicine may be higher or lower than before. Older adults especially may
be more likely to experience dizziness or a faint feeling when switching from tablets to
extended-release capsules. Follow your doctor’s instructions exactly for any dose changes with
Coreg or Coreg CR.

.

You may also take the Coreg capsule and open it to sprinkle the medication into a spoonful of
applesauce or pudding to make it easier for you to swallow. You must swallow this mixture
immediately, without chewing it. Do not save any unused mixture for later use, and be sure to
discard the empty capsule

Coreg should be stored at room temperature, and away from both moisture and heat.

If you miss a dose of Coreg you should attempt to take the missed dose as soon as you
remember. However, if it is almost time for your next scheduled dose do not take the missed dose
in addition to your regular dose.

Coreg Side Effects

If you experience any of the following adverse effects you should stop taking Coreg and seek
emergency medical help immediately:

• breathing difficulties
• chest pain, tightness or fluttering
• dry cough with wheezing
• faint feeling
• general ill feeling
• high blood sugar (signs include increased thirst, increased urination, hunger, dry mouth,
  fruity breath odor, drowsiness, dry skin, blurred vision and weight loss)
• hives
• loss of bladder control
• nausea
• numbness or cold feeling in your hands and feet
• pale skin with lightheadedness and a rapid heartbeat
• shortness of breath, even with mild exertion
• slow or uneven heartbeats
• severe skin reaction along with a fever, sore throat, swelling in your face or tongue, burning
  in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the
  face or upper body) and causes blistering and peeling
• swelling of your face, lips, throat, tongue, ankles, hands or feet, or swelling with rapid
  weight gain

Less serious Coreg side effects may include:

• cough
• decreased libido
• diarrhea
• dizziness
• drowsiness
• dry eyes
• impotence
• joint pain
• nausea
• vomiting
• weakness and tired feeling

It should be noted that this is not a complete list of possible side effects of Coreg. You
should contact your physician for a complete list and medical advice regarding these effects.

Coreg Description and Dosing

Coreg tablets are available in the following strengths:

3.125 milligrams, which are engraved with 39 and SB

6.25 milligrams, which are engraved with 4140 and SB

12.5 milligrams, which are engraved with 4141 and SB

25 milligrams, which are engraved with 4142 and SB

The 6.25 mg, 12.5 mg, and 25 mg tablets are TILTAB tablets.

All people taking Coreg should consult their doctor for specific dosing pertaining to them. Do
not attempt to alter or change your dose without your physician’s consent.

If you believe you may have overdosed with Coreg seek emergency medical help immediately.

Ingredients in Coreg

Coreg contains the active ingredient carvedilol. Inactive ingredients are colloidal silicon
dioxide, crospovidone, hypromellose, lactose, magnesium stearate, polyethylene glycol,
polysorbate 80, povidone, sucrose, and titanium dioxide.

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The information contained in this drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.