Brand Name

Zyprexa Zydis {Eli Lilly}

Generic Name

olanzapine, pronounced oh LANZ a peen

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Drug Guide

The information contained in the following drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.

What is Zyprexa Zydis?

Zyprexa Zydis is an atypical antipsychotic medication that is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder, which is also known as manic depression. Zyprexa Zydis is believed to work by changing the actions of chemicals in the brain. Adults and children age 13 and older may be prescribed Zyprexa Zydis along with other antipsychotic or antidepressant medications.

Zyprexa Zydis may also be used for purposes not listed in this medication guide.

Key Facts About Zyprexa Zydis

You should never take Zyprexa Zydis in larger amounts then directed, or for longer than recommended by your doctor.

You should not use Zyprexa Zydis for psychotic conditions related to dementia.

You should not drink alcohol while taking Zyprexa Zydis, as it may increase certain side effects of this medication, such as sleepiness.

Be aware that Zyprexa Zydis may impair your reactions or thinking. You should be careful when driving or doing anything which requires you to be alert, especially when you first start Zyprexa Zydis. Be careful when getting from a sitting or lying position, as Zyprexa Zydis can cause dizziness. Be sure to get up slowly and safely to prevent falling.

Tell your doctor if you are pregnant or plan to become pregnant. Zyprexa Zydis is in FDA pregnancy category C. It is known that taking an antipsychotic medication like Zyprexa Zydis, especially during the last 3 months of pregnancy, may cause problems in your newborn, like withdrawal symptoms, breathing problems, feeding problems, tremors, fussiness, and stiff or limp muscles. You should be aware that if you stop taking Zyprexa Zydis during your pregnancy you may have withdrawal symptoms. Consult with your doctor if you become pregnant while taking Zyprexa Zydis. You should not breast-feed while taking Zyprexa Zydis, as it is known that Zyprexa Zydis can pass into breast milk and may harm a nursing baby.

Tell your doctor if you have phenylketonuria (PKU), because Zyprexa Zydis may contain phenylalanine.

Before You Take Zyprexa Zydis

If you are allergic to olanzapine you should not take Zyprexa Zydis.

Let your doctor know if you have a history of low white blood cell counts, a history of breast cancer or liver disease before you start taking Zyprexa Zydis.

If you have epilepsy, seizures, a history of heart attack or stroke, or high or low blood pressure you should tell your doctor before taking Zyprexa Zydis.

Tell your doctor before starting Zyprexa Zydis if you have liver or kidney disease, high cholesterol or triglycerides, or a personal or family history of diabetes before you begin treatment with Zyprexa Zydis. You may gain weight or have high cholesterol and triglycerides while taking this Zyprexa Zydis, especially if you are a teenager.

You should inform your doctor if you have an enlarged prostate or difficulty urinating, bowel problems or narrow-angle glaucoma to make sure Zyprexa Zydis is right for you.

You may be more prone to heat stroke while taking Zyprexa Zydis. Be cautious about getting overheated or dehydrated during exercise and in hot weather.

Treatment with Zyprexa Zydis is not to be used for patients with psychotic conditions related to dementia. The use of Zyprexa Zydis for these patients may cause them extreme harm, such as heart failure, pneumonia, or even sudden death.

You should tell doctor if you have diabetes. Zyprexa Zydis may cause you to have high blood sugar, also called hyperglycemia. If you are diabetic, check your blood sugar levels regularly while you are being treated with Zyprexa Zydis.

Zyprexa Zydis Drug Interactions

You should inform your doctor if you are taking any of the following:

• carbamazepine (Carbatrol, Tegretol)
• diazepam (Valium)
• fluoxetine and olanzapine (Symbyax)
• fluvoxamine (Luvox)
• heart or blood pressure medications
• levodopa (Sinemet, Larodopa, Atamet)
• omeprazole (Prilosec)
• pramipexole (Mirapex)
• Prozac (fluoxetine)
• rifampin (Rifater, Rifadin, Rifamate)
• ropinirole (Requip)
• selegiline (Eldepryl, Emsam, Zelapar)

Other drugs you take that are not listed may interact with Zyprexa Zydis. You should tell your doctor about all of the medications you use. This includes prescription drugs, vitamins, supplements and herbal products, and over the counter medications. You should not begin taking a new medication without telling your doctor first.

Directions for Taking Zyprexa Zydis

You should take Zyprexa Zydis exactly as prescribed by your doctor. Do not take Zyprexa Zydis in larger or smaller amounts, or for shorter or longer than recommended. Follow the directions on your prescription label.

You should take Zyprexa Zydis at the same time every day.

You can take Zyprexa Zydis with or without food.

Zyprexa Zydis is an orally disintegrating tablet. To safely take this tablet you should keep the tablet in its blister pack until you are ready to use it. When you open the package you should carefully peel back the foil from the tablet blister. You should not push a tablet through the foil or you may damage it. You should use dry hands to remove the tablet and place it in your mouth. It will begin dissolving immediately. Do not chew or swallow the orally disintegrating tablet whole. You should allow it to dissolve in your mouth. You can swallow a few times to be sure the tablet has dissolved, or you can drink some water after it has dissolved.

Zyprexa Zydis is a part of a program that your doctor has prescribed which may include
counseling and other psychological support program. Follow your doctor’s instructions exactly and tell your doctor if your symptoms do not improve, or if they get worse while using Zyprexa Zydis.

Be aware that Zyprexa Zydis may cause you to have high blood sugar, also called hyperglycemia. Tell your doctor right away if you have symptoms of hyperglycemia like increased thirst, excessive hunger, excessive urination or weakness. If you are a diabetic you should check your blood sugar levels on a regular basis while you are taking Zyprexa Zydis.

Do not stop using Zyprexa Zydis without consulting your doctor, as you may experience adverse side effects if you stop taking this medication suddenly. Your doctor may change your dosage of Zyprexa Zydis throughout the course of your treatment, and you should follow his or her instructions carefully.

Zyprexa Zydis needs to be stored at room temperature, and away from light, moisture and heat.

If you miss a dose of Zyprexa Zydis you should attempt to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose do not take the missed dose in addition to your regular dose.

Zyprexa Zydis Side Effects

If you experience any of the following adverse effects you should stop taking Zyprexa Zydis and seek emergency medical help immediately:

• allergic reaction such as breathing difficulties, hives, swelling of your face, lips, throat or tongue
• clay colored stools
• confusion
• dry mouth and skin
• faintness
• fever
• flu like symptoms
• fruity breath odor
• hallucinations
• headache
• increased heart rate
• increased thirst and urination
• jaundice
• numbness or weakness which is sudden and may include problems with your vision, speech, or balance
• sores in your throat or mouth
• speech problems
• stiff and rigid muscles with a high fever, tremors, sweating, confusion, fast or uneven heartbeat, slow heart rate or feeling like you might pass out
• suicidal thoughts or thought about hurting yourself
• trouble speaking or swallowing
• twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs
• urinating less than usual or not at all
• darkened urine
• upper stomach pain with itching and loss of appetite
• vomiting

Less serious side effects of Zyprexa Zydis may include:

• increased appetite
• breast swelling or discharge (in women or men)
• constipation
• dizziness
• drowsiness
• headache
• insomnia
• loss of bladder control
• memory problems
• missed menstrual periods
• numbness and tingling
• pain in arms, legs or back
• feeling tired
• trouble swallowing
• upset stomach
• weakness
• weight gain, particularly in teenagers

It should be noted that this is not a complete list of possible side effects of Zyprexa Zydis. You should contact your physician for a complete list and medical advice regarding these effects.

Zyprexa Zydis Description and Dosing

Zyprexa Zydis is available as orally disintegrating tablets in dosages of 5 mg, 10 mg, 15 mg and 20 mg strengths. The Zyprexa Zydis orally disintegrating tablets are not scored, and are yellow, round, and debossed with the tablet strength.

Because Zyprexa Zydis is prescribed differently for each patient and their unique condition, all people taking Zyprexa Zydis should consult their doctor for a specific dosing pertaining to them. You should not attempt to alter or change your dose without your physician’s consent.

If you suspect that you have overdosed with Zyprexa Zydis you should seek emergency help immediately.

Ingredients in Zyprexa Zydis

The primary active ingredient in Zyprexa Zydis is olanzapine. Inactive ingredients include gelatin, mannitol, aspartame, sodium methyl paraben, and sodium propyl paraben.

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The information contained in this drug guide is intended as an educational resource only. This guide is not exhaustive and does not contain all available information about this drug.This guide is not intended as medical advice for individual conditions or treatment.

The information provided in this guide does not replace the need for the advice and services of medical professionals or the need for medical examination. Always talk to your physician or pharmacist before taking any prescription medication or over the counter drugs (including any supplements) or before making any changes to your treatment. Only your doctor, nurse or pharmacist can provide you with safe and effective advice regarding your drug treatment.

The use of the information in this guide is at your sole risk. This information is provided "AS IS" with no warranties to accuracy or timeliness.

**All trademarks and registered trademarks are the property of their respective owners.